Monday, 23 April 2012 |
Microfluidic Chemistry |
| | 09:00 |  | Keynote Presentation Optimization and Scale-up of Flow Chemistry Processes
Klavs Jensen, Professor, Massachusetts Institute Of Technology, United States of America
Automated optimization and scaling techniques for flow reactors are presented with examples drawn from fine chemicals and pharmaceutical intermediates. |
| 09:30 | Strategic Applications of Flow Chemistry within Drug Discovery
Paul Richardson, Senior Principal Scientist, Pfizer Worldwide Research and Development, United States of America
A focus on Flow Chemistry applications within Medicinal Chemistry programs in which the Flow solution brings a tangible benefit, either in terms of accessibility of chemical space, enhanced reactivity or expedited scalability of the ensuing chemistry to expedite the program.
| 10:00 | Improving Organic Synthesis by Exploiting Flow Reactor
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa
The application of flow reactors to efficiently optimise a range of different chemical reactions will be described. | 10:30 | Coffee Break and Networking in Exhibition Hall | 11:15 |  | Keynote Presentation Continuous Flow Multi-step Organic Synthesis - Methods and Applications
Timothy Jamison, Robert R. Taylor Professor and Department Head, Massachusetts Institute of Technology, United States of America
Several case studies regarding the identification, development and implementation of new methods of continuous organic synthesis will be presented. |
| 12:00 | Lunch Break and Networking in Exhibition Hall | 13:30 | Poster Session | 14:15 |  | Keynote Presentation Microreactors and Copper (I) Catalysis: An Effort Towards More Efficient Synthesis
Tyler McQuade, Associate Professor, Florida State University, United States of America
Continuous chemistry is a central theme of the McQuade group, inspiring and enabling the production of structured materials, creation of efficient synthetic routes and development of novel catalysts and catalytic methods. |
| 14:45 | Continuous Flow Reactors for Gas/Liquid Chemical Processes
Graham Sandford, Professor, Durham University, United Kingdom
The use of single and multichannel continuous flow reactors for gas/liquid fluorination and oxidation reactions will be described. | 15:15 | Coffee Break and Networking in Exhibition Hall | 16:00 | Expanding Flow Chemistry: On-demand Gas Addition, Organic Synthesis, Photochemistry and Inorganic Chemistry
Nicholas Leadbeater, Associate Professor, University of Connecticut, United States of America
| 16:30 | Catalysis in Flow: Recent Examples from Pharma
Matthew Yates, Research Scientist, Lilly, United States of America
This talk will outline Lilly’s strategy and implementation of this technology over the past several years with a focus on the area of catalysis. Project examples will be presented from laboratory proof-of-concept studies to kilo scale production. | 17:00 | Drinks Reception |
Tuesday, 24 April 2012 |
New Directions in Flow Chemistry |
| | 09:00 |  | Keynote Presentation Hybrid ROMP Oligomers: Synthesis, Properties and Application in Parallel and Flow Platforms
Paul Hanson, Professor, University of Kansas, United States of America
The development of hybrid ROMP-derived reagents with tunable properties is reported. These reagents include, new phosphorus-based oligomers, silica-supported ROMP reagents and Nb-tagged Cobalt-graphite (Nb-Co/C) magnetic nanoparticles for use in parallel and flow platforms. |
| 09:30 | Integration of Continuous Flow Reactors and Process Analytical Technology for Real-time Release Testing
Brian Marquardt, Director, University of Washington, United States of America
Development and implementation of accurate sampling systems and advanced analytics will greatly speed the development of new chemistries, streamline reaction optimization and vastly improve production quality and control in continuous flow reactors. | 10:00 | Flow Chemistry for Designing Sustainable Chemical Synthesis
Michael Gonzalez, , US Environmental Protection Agency, United States of America
The advantages offered by Flow Chemistry are increasingly being recognized and placed into practice. By adding the principles of Green Chemistry and Engineering, these advantages are further realized along with an associated increase in the sustainability of the chemical transformation. | 10:30 | Coffee Break and Networking in Exhibition Hall | |
Lab to Pilot Scale |
| | 11:15 | Flow Processes in Specialty Chemicals Manufacture
Martin Cohen, Sr Research Fellow, CYTEC Specialty Chemicals , United States of America
The manufacture of specialty chemicals places specific requirements on the attributes that a continuous flow process must provide to be profitable. These requirements will be examined by several case studies. | 11:45 | Applications of Flow Chemistry in Pharmaceutical Processing
Frank Gupton, Floyd D. Gottwald Chaired Professor, Virginia Commonwealth University, United States of America
| 12:15 | Lunch Break and Networking in Exhibition Hall | 13:30 | Poster Session | 14:15 | Flow in Life Science Product Manufacturing
David Ager, Principal Scientist, DSM Pharma Chemicals, United States of America
Flow chemistry is becoming established as the preferred method for reactions where safety, either due to large exotherms or hazardous intermediates, is paramount. A number of different examples will be given. | 14:45 | Process Safety Considerations in Developing a Flow Process for the Pilot Plant
Martin Guinn, Director Process Safety and Engineering Technologies, Pfizer, United States of America
| 15:15 | Coffee Break and Networking in Exhibition Hall | 16:00 | Enhanced Development and Control of Continuous Processes using Real Time In Situ FTIR Analytics
Dominique Hebrault, Senior Technology and Application Consultant, Mettler Toledo AutoChem Inc, United States of America
The combination of flow reactor technology and in situ analysis equipped with multivariate analysis and data-to-information software modules, are used in flow chemistry and crystallization design to minimize waste, improve reaction output and decrease the formation of by-products. | 16:30 | Organic Synthesis in Flow: New Reactions to High Value Products
Floris Rutjes, Professor, Radboud University Nijmegen, Netherlands
New continuous flow reactions with integrated workup, monitored using in-line analysis techniques, will be presented. Examples include the synthesis of fine chemical intermediates and high value end products such as PET tracers. | 17:00 | Close of Conference |
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