1st International Conference of The Flow Chemistry Society Agenda

Registration

Running Hazardous Chemistry in a Flow Environment
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria

In this presentation, the safe use of hydrazoic acid, a highly toxic and explosive reagent, in scalable flow chemistry applications is described. In addition, examples of flow ozonolysis are also presented.

Continuous Flow Reactors for Gas/Liquid Chemical Processes
Graham Sandford, Professor, Durham University, United Kingdom

The use of single and multichannel continuous flow reactors for gas/liquid fluorination and oxidation reactions will be described.

Coffee and Networking in Exhibition Hall

Expanding the Range of Industrial Reactions by Microreactor Technology
Christian Stevens, Senior Full Professor, Ghent University, Belgium

The inherent characteristics of microreactor technology expand the possibilities of a range of reactions which could not be safely performed on an industrial scale. The lecture will focus on reactions including dangerous reagents, renewable resources and multi-component reactions.

A Variation on CSTRs that Makes all the Difference
Gilda Gasparini, Continuous Reactor Manager, AM Technology, United Kingdom

Coflore ACR is a flexible flow reactor following the principle of multi stage CSTRs. Examples will be given of its ability to handle multiphase systems and long reaction times at the lab and production scale.

Eschweiler Clark Reaction: Optimization and Scale up from Batch to Continuous
Luc Moens, Research Fellow, Johnson & Johnson, Belgium

Kinetic modeling is used as a development tool to optimize and scale up a chemical reaction from batch to the most ideal flow conditions.

Lunch and Networking in Exhibition Hall

Poster Viewing

New Opportunities for Synthesis using Flow Chemistry
Thomas Wirth, Professor, Cardiff University, United Kingdom

Biphasic reactions, hazardous reagents and unusual reaction conditions allow novel reactions under flow conditions.

A Multi-chip Setup for Analysis of Several Antihistamines in Pharmaceutical Formulations Using Tris (1,10-Phenanthroline) - Ruthenium(II) Peroxydisulphate Chemiluminescence (CL) System
Haider Al Lawati, Associate Professor , Sultan Qaboos University, Oman

In this presentation, a multi-chip device consists of micro-reactors and a micro-mixer is described. The use of such devise in analysis of several anti histamines is also presented.

Coffee and Networking in Exhibition Hall

Enabling Technologies in Organic Chemistry: From Miniaturized Flowreactors to New Heating Concepts
Andreas Kirschning, Group Leader, Leibniz University of Hannover, Germany

Photochemistry and Reactive Intermediates in Flow
Alexander Brien, Researcher, Max Planck Institute of Colloids and Interfaces, Germany

This presentation describes our recent research into the generation of reactive intermediates via thermal and photochemical techniques in flow reactors.

Accessing New Chemical Space Through Flow-Enabled “Forbidden” Chemistries
Neal Sach, Associate Research Fellow, Pfizer, United States of America

A flow technology is presented with the capability to run and analyze 100-300 reactions per day. The application of this technology in accessing new chemical space in drug discovery is presented, with examples of chemistries, traditionally considered ‘forbidden’ in batch, exemplified.

The Utilization of Inline FTIR and Flow Technology for Real Time Reaction Optimization and Monitoring
Gabor Szirbik, POC Development Manager, ThalesNano, Hungary

Modern continuous flow technologies offers rapid testing, optimization, and scaling of chemical sequences, often leading to more efficient reactions than under batch conditions. In order to overcome the limitation of off-line analysis ThalesNano flow equipments were combined with ReactIR™ flow cell providing convenient inline analytical tool.

Drinks Reception

Azide Synthesis in Microstructured Flow Systems with Integrated Work-Up
Gregor Wille, Senior Scientist, Sigma Aldrich, Switzerland

Aromatic azide synthesis starting from substituted anilines in a two-stage flow process. The products are isolated as 0.6 – 1.1 M solution in organic solvents after integrated extraction. This operation enables safe handling of the hazard reagents an intermediates.

Microreactors as Efficient Vehicle to Study Different Types of (Catalyzed) Organic Reactions
Willem Verboom, Professor, University of Twente, Netherlands

Coffee and Networking in Exhibition Hall

Continuous Flow Prilezhaev Alkene Oxidation: Optimization and Scale Up
Floris Rutjes, Professor, Radboud University Nijmegen, Netherlands

The continuous flow peracid-mediated epoxidation of alkenes was taken as a model reaction to show that microreactors can be successfully applied to optimize hazardous reactions, and subsequently scale them out to larger scale production.

Microfluidic Flow Techniques for High-density Reaction Informatics
Robert Wootton, Lecturer/Senior Scientist, ETH Zurich, Switzerland

Microreactors coupled to sensors have been used for reaction optimisation. High definition sensors such as ESI-TOF mass spectrometers are used in this way to investigate mechanisms of complex or anomalous reactions.

Technology Spotlight:
Enhanced Development and Control of Continuous Processes
Michael Kleimann, Area Technical & Application Consultant, Mettler Toledo

One of the main analytical challenges for continuous chemistry is real-time inline monitoring for enhanced understanding and control of reactions, especially when dealing with multistep sequences. This presentation will discuss ReactIR™ in situ IR spectroscopy and the latest flow chemistry technology available as well as case studies showing how this technology monitors and provides reaction feedback on control parameters for immediate understanding and optimization of processes.

Lunch and Networking in Exhibition Hall

Poster Viewing

Flow Synthesis Integrated with Biological Screening
Chris Selway, Chief Technology Officer, Cyclofluidic Ltd, United Kingdom

This presentation will outline progress in combining the key elements of flow synthesis and flow bioassay into an integrated platform capable of rapid generation of new molecular entities and corresponding biological activity data to support modern drug discovery programmes.

Coffee and Networking in Exhibition Hall

Spectroscopic and Calorimetric Monitoring of Microfluidic Processes
Stefan Lobbecke, Head of Department, Energetic Materials, Fraunhofer Institute for Chemical Technology, Germany

Fast spectroscopic and calorimetric techniques are presented which allow monitoring of chemical reactions in microfluidic processes with a high degree of temporal and spatial resolution.

The Utility of Enabling Chemistry Technology for Improving Drug Discovery Cycle Time
Stevan Djuric, Senior Director, Discovery Chemistry and Technology, AbbVie, United States of America

The use of enabling chemistry techniques including meso flow and flow photochemistry for reducing cycle time and for the production of novel chemical structures for High Throughput Screening campaigns will be discussed.

Microwave Solid-Phase Synthesis
Fernando Albericio, Group Leader, University of Barcelona, Spain

Close of Conference