Lab-on-a-Chip European Congress Agenda

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Microfluidic Devices for Long-Term 3D Cell Culture and Anticancer Drug Activity Evaluation
Zbigniew Brzozka, Professor, Warsaw University of Technology, Poland

The presentation will concern applications of microfluidic devices for cell culture and testing. Long-term two-dimensional and three-dimensional cell culture on-chip for anticancer drugs activity evaluation and photodynamic therapy testing will be discussed.

Tubeless Microfluidic Systems for Personalized Chemotherapy
Albert Folch, Professor of Bioengineering, University of Washington, United States of America

Presently, oncologists do not directly assess tumor chemosensitivity prior to choosing a chemotherapeutic regimen, resulting in inefficient therapies. Here we show a multiplexed microfluidic assay that utilizes intact tumor tissue and could be used to rapidly predict tumor chemosensitivity to a large panel of drugs prior to initiation of therapy.

Coffee Break & Networking in Exhibition Hall

Manipulating Magnetic Cells and Particles On-chip
Nicole Pamme, Professor in Analytical Chemistry, Stockholm University, Sweden

Microfluidics based approaches are presented for manoeuvring magnetically doped particles or magnetically labelled cells through fluidic interfaces by means of externally applied forces.

Paper-based Microfluidics: Something Old + Something New
Andrew Steckl, Gieringer Professor, Ohio Eminent Scholar, University Distinguished Research Professor, University of Cincinnati, United States of America

Paper-based microfluidic lab-on-chip devices using capillary flow provide an attractive alternative to conventional microfluidic devices in resource-poor and point-of-care environments. This presentation reviews this rapidly expanding field for low cost and simple to use bio/medical and other applications.

Technology Spotlight:
Case Study “Heart Check” and Manufacturing with Different Technologies for Medical Consumable Devices for Analytic and Diagnostics – Single Sourced
Harald Denz, MD & CEO,

This talk will be about a heart test instrument to be used at home by the patient, the results will be transmitted to the family doctor via GPRS. The cooperation with the customer was to support the development of the technical implementation of LOC plastic components. z-microsystems itself develops LOC-technologies which allow to manufacture components with increasingly finer and thinner structures.

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Integrated Inertial Pump for Micro-fluidic Application
Alexander Govyadinov, Senior Technologist, HP Incorporated, United States of America

The low-cost integrated inertial micro-pump is investigated. CFD model and variety of tested microfluidic geometries with pump’s array demonstrated feasibility of the inertial micro-pump technology. Potential applications of small form-factor integrated micro-fluidic pumps for Lab-on-Chip application is discussed.

Coffee Break & Networking in Exhibition Hall

Isotachophoresis in Microchannels: Beyond Separation of Analytes
Steffen Hardt, Professor, University of Technology Darmstadt, Germany

We show that microchannel isotachophoresis (ITP) displays a rich variety of interesting physical phenomena that may be utilized for a much broader scope of applications than only the separation of analytes. We demonstrate this by a number of examples, including ITP-based “digital microfluidics” and particle separation at ITP transition zones.

Biophotonic Lab on a Chip for Simultaneous Cell Retention and Monitoring
Xavier Muñoz, Senior Researcher, Microelectronics Institute of Barcelona (IMB-CNM), Spain

A biophotonic lab on a chip consisting on twin chambers and size-exclusion micofilters for real time cell retention and monitoring will be presented. As a proof of concept, they have been used for separate mixtures E-coli and S. cerevisiae and for pH monitoring of VSMC cultures.

High Throughput Fluorescence Detection of Phytoplankton using an Optofluidic Biosensor
Nastaran Hashemi, Assistant Professor, Iowa State University, United States of America

We have deigned an optofluidic biosensor for high throughput characterization of phytoplankton by their intrinsic fluorescence and light scatter. Phytoplankton with a wide range of sizes and shapes are successfully detected using this approach.

Round Table Discussions in Exhibition Hall

Cartridge Based Magnetic Immunodiagnostic Platform for Sensitive Point-of-care Testing (POCT) of Biomarkers and Viral Pathogens
Raiah Gottheil, Researcher, NMI , Germany

A microfluidic platform for sensitive and quantitative detection of diagnostic targets suitable for POCT is reported. Targets are detected through a magnetic bead fluorescence immunoassay. The beads constitute the solid phase for immobilization of capture molecules additionally are meant for mixing and incubation with various assay reagents. The actuation scheme allows periphery to be minimized. Evaluation done using an Inlterleukin-8 assay yielded detection limits of 1.25 pM.

Will Micro Total Analysis Systems (µTAS) Become Consumer Products?
Benjamin Roussel, Business Unit Manager of the Microfluidic & Medical Technologies (MedTech), Yole Développement, France

The concept of self-conducted diagnostic tests, administered by patients everywhere, is slowly becoming a reality. This presentation underlines the potential of Micro total analysis Systems to serve the consumer-driven Healthcare of tomorrow.

Coffee Break & Networking in Exhibition Hall

Optothermal Actuation of Nanofluidic DNA Chips
Anders Kristensen, Associate Professor, Technical University of Denmark, Denmark

A nanoimprinted polymer chip  with a thin near-infrared absorber layer is used to create local hot-spots by absorption of an infrared laser beam. Large temperature at gradients at the hot-spot yields thermophoretic forces, which are used to manipulate and stretch individual DNA molecules confined in nanochannels.

Improving Microfluidic Interfacing by Using SideConnect Technology
Mark Olde Riekerink, Senior Business Development Manager, Micronit Microtechnologies BV, Netherlands

Micronit is developing a new type of fluidic connection, in addition to its currently standardized Fluidic Connect Pro platform. The SideConnect technology simplifies the microfluidic chip/cartridge design and thus reduces product costs. With no access holes in the top layer, this technology can be implemented either in a 2D (in-plane) or a 3D (out-of-plane) configuration.

Technology Spotlight:
Microfluidics and Sacral Buildings: What Can We Learn from Sagrada Familia
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH

Lunch & Networking in Exhibition Hall

Poster Viewing Session

From Microfluidics to Lab on a Chip Technology - Challenges and Achievements
Stephen Haswell, Professor , Deakin’s Centre for Regional and Rural Futures, Australia

This presentation will consider how to move from micro fluidics to lab on a chip technology through the design and fabrication of systems and process integration, to create devices with a high level of functionality that can be manufactured at volume.

Integrated Handling and Analysis of Complex Biosamples on a Microfluidic Lab-on-a-disc System
Jens Ducree, Professor of Microsystems, Dublin City University, Ireland

This presentation surveys various strategies to integrate sample preparation, reagent storage, and analysis of complex biofluids for a range of test formats such as immunoassays, molecular diagnostics and cell counting towards a versatile, centrifugal microfluidic sample-to-answer platform.

Coffee Break & Networking in Exhibition Hall

OSTE - A New Paradigm in Lab on Chip Manufacturing
Fredrik Carlborg, Project Manager, KTH Royal Institute of Technology, Sweden

We will present Off-Stoichiometry Thiol-Ene (OSTE) based polymers as the first polymers specifically designed for lab-on-chip applications. We will demonstrate their basic properties and characteristics, including mechanical tenability, ease of surface modification and room temperature bonding.

Single Cell Transfection with Single Molecule Resolution Using a Nanopore
Volker Kurz, Researcher, University of Notre Dame, United Kingdom

Single cell transfection along with non-optical single molecule detection with a nanopore offers the prospect of a paradigm shift for detecting the sectretome extending the frontier of biology towards single cell analysis and transfection with single molecule resolution.

Close of Conference