Tuesday, 25 September 201208:00 | Registration | | New Applications in Microfluidics |
| | 09:00 | Tubeless Microfluidic Systems for Personalized Chemotherapy Albert Folch, Professor of Bioengineering, University of Washington, United States of America
Presently, oncologists do not directly assess tumor chemosensitivity prior to choosing a chemotherapeutic regimen, resulting in inefficient therapies. Here we show a multiplexed microfluidic assay that utilizes intact tumor tissue and could be used to rapidly predict tumor chemosensitivity to a large panel of drugs prior to initiation of therapy. | 09:30 | Microfluidic chips for photo- and radiochemistry Nicole Pamme, Professor in Analytical Chemistry, Stockholm University, Sweden
Miniaturising chemical processing to the microfluidic scale allows for precise control of reaction conditions. Two examples of efficient microfluidic chemistry are presented: (i) photo-chemistry for light initiated reactions and (ii) radiochemistry for dose-on-demand PET imaging tracers. | 10:00 | Preparation of Nucleic Acid Libraries for Personalized Sequencing Systems Using an Integrated Microfluidic Hub Technology Kamlesh Patel, R&D Advanced System Engineering and Deployment Manager, Sandia National Laboratories, United States of America
Integrated Digital Microfluidic Hub for Automating Library Construction for Next generation Sequencing Systems
| 10:30 | Coffee Break & Networking in Exhibition Hall | 11:15 | Stable Capillary Stop Valves in Highly Hydrophilic Materials for Passive Microfluidic Systems Marko Blom, Chief Technical Officer, Micronit Microtechnologies, Netherlands
At Micronit Microfluidics, we have fabricated passive capillary stop valves in untreated hydrophilic glass although the general design can be applied to any highly hydrophilic material. These valves demonstrate stable stopping of capillary pressure driven liquid. The valves can be triggered on demand for sequential flow microfluidic applications such as lab-on-a-chip immunoassay. | 11:45 | Microfluidic Tools for Personal Exposure Assessment Charles Henry, Professor and Chair, Colorado State University, United States of America
This talk will focus on recent
work in our laboratory focused on developing paper-based analytical devices for analysis of
pollutants in aerosolized particulate matter at the personal level.
| 12:15 | Technology Spotlight: Customer Project “Heart Check” and Manufacturing of LOC / Microfluidic components with different technologies for Medical Products. Harald Denz, MD & CEO,
This is about a heart test instrument to be used at home for the customer and the results transmitted via GPRS to the house doctor. The cooperation with the customer was to support the development of the technical implementation of LOC plastic components during development in the technical implementation to support. The company itself develops technologies in her own technology center which allow manufacturing components with increasingly finer and thinner structures. The mirror surfaces in the plastic injection molding tools support the use of lasers in research and applications of microfluidics. | 12:30 | Lunch & Networking in Exhibition Hall | 13:30 | Poster Viewing Session | 14:15 | Microfluidics for Engineering 3D Tissues and Cellular Microenvironments Brian Gillette, Post Doctoral Fellow, Columbia University, United States of America
This presentation describes several methods that integrate microfluidics and 3D biomaterials for engineering tissues and in vitro cellular microenvironments for applications in regenerative medicine and biological studies. | | Single Cell Analysis |
| | 14:45 | | Keynote Presentation Isolation and Analysis of Circulating Tumor Cells Daniel Chiu, A. Bruce Montgomery Professor of Chemistry, University of Washington, United States of America
This presentation will describe an approach called ensemble decision aliquot ranking (eDAR) for the isolation and analysis of circulating tumor cells and other rare cells present in circulation
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| 15:15 | Coffee Break & Networking in Exhibition Hall | 16:00 | Microchip Electrophoresis: On-Animal Sensors and Single Cell Analysis Susan Lunte, Professor, University of Kansas, United States of America
Microdialysis sampling combined with microchip electrophoresis yields a separation-based sensor that can be used to continuously monitor neurotransmitters and nitric oxide metabolites in awake freely roaming animals. The very fast separations achievable with these devices also make it possible to detect labile reactive nitrogen species in single cells.
| | Microfluidics Continued... |
| | 16:30 | Microfluidic Digital Logic for the Autonomous Lab-on-a-Chip Elliot Hui, Associate Professor of Biomedical Engineering, University of California-Irvine, United States of America
We are building digital microcontrollers entirely out of microfluidic components, without electronics, allowing controls to be integrated with fluid handling on a self-contained chip. We demonstrate a clock, a finite-state machine controller, and a metering and mixing circuit.
| 17:00 | A Linear Array of Unique Microfluidic Gradients for Enzymatic Bioassay Matthew Estes, Postdoctoral Research Associate, Center for Applied NanoBioscience and Medicine, University of Arizona, United States of America
The authors present a single chip capable of generating a linear array of unique diffusion-based gradients in a variety of microchannels in parallel. | 17:30 | Drinks Reception |
Wednesday, 26 September 2012 | Microfluidic Devices |
| | 09:00 | Inertial Microfluidic Devices for Cell Separations Ian Papautsky, Professor, University of Cincinnati, United States of America
Separation and isolation of cells from a mixture remains to be a critical technical challenge, especially when cells are rare. This talk will focus on inertial microfluidic devices for continuous separation of cell mixtures with high selectivity and throughput. | 09:30 | Microelectronics Meets Microfluidics: Hybrid Integration of Sensors in Microfluidic Devices Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH, Germany
In addition to the well established optical detection methods, a recent development in lab-on-a-chip technology is the increased use of sensor technology for the detection of analytes in a microfluidic system. These sensors can range from relatively simple electrochemical sensors to electronically read-out microarrays or highly integrated nano-electrode sensors with on-chip signal processing capabilities. These sensors require innovative technological solutions for their integration into a microfluidic cartridge. We will present solutions for such integrated systems for the detection of biomarkers, proteins and nucleic acids for applications in rapid infectious disease identification or drug efficacy monitoring.
| | Diagnostics and Medical Approaches |
| | 10:00 | | Keynote Presentation Integrated Molecular Diagnostics with Bionanoscience for Innovative Global Healthcare Research & Technology (iMDx BIGHEART) Luke Lee, Director, Global Health Research and Technology (BIGHEART), NUS, United States of America
I will discuss Integrated Molecular Diagnostic Systems (iMDx) for preventive global healthcare and personalized medicine, BASICs (Biofluidic Application Specific Integrated Circuits) with satellite nanoscopes for quantitative nanobiology and organ-on-a chip. |
| 10:30 | Coffee Break & Networking in Exhibition Hall | 11:15 | Five Tips for Successful Commercialization of Lab-on-Chip Diagnostics Erol Harvey, Chief Executive Officer, MiniFAB, Australia
Successful technology transfer from laboratory prototype to full-scale manufacture of medical diagnostic products is about managing complexity. The growing field of lab-on-chip point-of-care devices is an opportunity growth area. MiniFAB will share five tips for successful commercialization of lab-on-chip diagnostics. | | Point-of-Care Diagnostics |
| | 12:15 | Technology Spotlight: Enabling Smart Consumable Devices for Biosciences and Diagnostics - Cost Drivers and Technologies Jessica Melin, Senior Manager, Sony Dadc Austria AG
Providing high quality consumable devices at application compliant cost is critical for diagnostic platforms. Such devices increasingly demand mass manufactured polymer microstructures. This talk discusses the important interplay between device mass manufacturability, cost drivers, and detection principles. | 12:30 | Lunch & Networking in Exhibition Hall | 13:30 | Poster Viewing Session | 14:15 | Capillarity-based Paper Networks for Automated Point of Care Diagnostics Barry Lutz, Research Assistant Professor, University of Washington, United States of America
Biochemical diagnostics are typically run in a lab by an expensive instrument or a trained human. We are exploiting properties of shaped paper to “program” disposable devices that run multi-step biochemical diagnostics without an instrument at a cost and ease-of-use comparable to a pregnancy test. | | Microfabrication and Engineering |
| | 14:45 | Direct-Write of 3D Functional Biomaterials using Projection Stereolithography Shaochen Chen, Professor, The University of California San Diego, United States of America
Dr. Chen will discuss a novel digital projection stereolithography microfabrication platform for 3D biomaterial scaffolds, which allows control over properties including stiffness, pore-sizes, Poisson’s ratio in three dimensions for 3D tissue engineering.
| 15:15 | Coffee Break & Networking in Exhibition Hall | 15:45 | Micromachining Technologies for Configurable 3D Biochips Carlotta Guiducci, Professor, Ecole Polytechnique Federale De Lausanne, Switzerland
Configurable electronic biochips with improved robustness towards the wet environment would enable the widespread use of CMOS-based systems in bioanalytics and personalized medicine. An innovative technology for 3D semi-disposable biochips featuring microelectrode arrays is presented. | 16:15 | Close of Conference |
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