Multi-Cancer Early Detection Based on a Classifier for Extracellular Vesicle Biomarkers
Jean Lewis,
Director, Research,
Biological Dynamics
Simultaneous detection of multiple, early-stage cancers was tested using extracellular vesicle (EV) bound protein markers from plasma purified by an alternating current electrokinetic (ACE) microarray. In a case-control study, this method detected 95.7% of pancreatic, 75.0% of ovarian, and 43.8% of bladder cancers at 99.5% specificity, all at stage I. The initial results suggest that this liquid biopsy screen may have great promise for early stage, multi-cancer screening.
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