Rapid and Column-Chromatography-Free Flow-Peptide Chain Elongation
Shinichiro Fuse,
Professor,
Nagoya University
Peptides have become increasingly important as drugs. In this study, we developed rapid, mild and column-free peptide chain elongation via one-flow, three-component coupling approach using amino acid N-carboxy anhydride (NCA) which has both nucleophilicity and electrophilicity. The key to success was the rapid generation of acid chloride from amino acid and its rapid coupling with NCA via rapid dual activation.
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