MPS Platforms with High Operability for Commercialization
Hiroshi Kimura,
Associate Professor,
Tokai University
Microphysiological systems (MPSs) have been widely studied as a novel
method for estimating the effects and toxicities of drugs, providing an
alternative to animal tests in drug discovery. In EU and USA, various
types of MPS are commercially available by some companies, and more
recently, their practical application has been well promoted. Although
MPS has been actively researched in Japan, there has been almost no
practical MPS to date. Japan Agency for Medical Research and Development
(AMED) has conducted an MPS development project with the aim of
commercializing domestically produced MPS since 2017. Our research group
has developed two types of MPS, Fluid3D-X and Kinetic pump Integrated
Microfluidic Plate, for commercialization in collaboration with Japanese
manufacturing companies in the project. Our proposed MPSs are expected
to facilitate high quality cell-based assays in drug discovery and
biology due to their ease of use and high throughput. In this
presentation, I present the overview of these MPS’s functions and
examples of the drug evaluation studies using the MPSs.
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