Tumor Microenvironment 3D Cell Models to Address Therapeutic Response
Giacomo Domenici,
Associate Scientist,
Instituto de Biologia Experimental e Tecnológica (iBET)
The presentation will focus on the following topics:
- Representation of the Tumor microenvironment (TME) is critical to study response to advanced therapeutics.
- Different strategies to represent the TME, developed in the Lab will be presented, based on 3D cell culture models, namely:
- Reconstruction modeling strategies, involving cancer cell line derived spheroids and non-malignant TME cellular components co-cultures (e.g., fibroblasts, macrophages).
- Preservation modeling approaches employing patient-derived tumor tissue for translational and clinical research.
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