The Next Big Small Things: Technology Driven Approaches to Bring Extracellular Vesicles into the Clinic
Sunitha Nagrath,
Professor of Chemical Engineering and Biomedical Engineering,
University of Michigan-Ann Arbor
Small nanoscale extracellular vesicles (EVs), known as exosomes,
represent a rapidly emerging biomarker for cancer detection by liquid
biopsy. Given the tiny amount of cargo carried by these nano-sized
vesicles, the development of techniques that can analyze these important
carriers is an active area of research in recent times. Additionally,
while high in information content, the current exosomes profiling
protocols are lengthy, preventing their widespread utilization and
cancer diagnostics in a timely manner. Recent advances in technologies
and approaches will be discussed to isolate and probe exosomes. We
present the isolation of tumor derived EVs and their molecular cargo for
rapid cancer diagnosis and in-depth mutation profiling.
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