Modeling Cancer Prevention In Breast Organoids
Jennifer Rosenbluth,
Instructor in Medicine,
Dana-Farber Cancer Institute
Mammary organoids can be used to preserve complex lineages in long-term culture. Using mass cytometry to profile cell states in patient-derived breast organoids, we identify a cell population that is expanded in the breast tissue of BRCA1/2 mutation carriers. This approach is being extended to model early stages of cancer development as well as aggressive breast cancer subtypes.
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