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SELECTBIO Conferences Flow Chemistry Congress 2018

Flow Chemistry Congress 2018 Agenda

Fully Continuous Mulit-Step GMP Synthesis of Drug Substance in a Fume Hood Facility

Joel Calvin, Research Scientist, Eli Lilly

Development and implementation of flow process to make drug substance that include a Buchi operation for solvent exchange, Grignard formation using magnesium in a CSTR, a Negishi reaction in a solids handling PFR and a continuous anti-solvent/cooling crystallization of API. The process was run at our manufacturing small volume continuous facility.