Aurelio Lorico,
Professor of Pathology
Aurelio Lorico did his post-doc at Yale University, mentored in the pharmacology field by Alan Sartorelli. Later, as Junior Research Faculty at Yale he clarified the biological function(s) of the MRP1 gene by generating and characterizing MRP1 knockout mice and cell lines. After 8 years at Yale, he became senior scientist at the Norwegian Cancer Center in Oslo, working on cancer drug resistance and designing new strategies for gene therapy of hereditary diseases. Back to the US, he has been working on cell-to-cell communication in the tumor microenvironment, particularly cell-cell fusion and extracellular vesicles, and on the development of innovative therapeutic strategies for breast cancer, melanoma and glioblastoma. His lab has recently discovered the mechanism of nuclear transport of the cargo of extracellular vesicles and has synthesized new drugs that block the transport and have anti-cancer metastatic activity.
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