Dik van Gent,
Associate Professor
Dik van Gent studied biology in Utrecht and did his PhD research at the Netherlands Cancer Institute (Amsterdam) under the supervision of Prof. R.H.A. Plasterk. He investigated various aspect of the HIV DNA integration reaction. After receiving his PhD in 1993, he did three years of post doc research at the National Institutes of Health in Bethesda (USA) under the supervision of Dr. M. Gellert.
During most of this time he was supported by an EMBO long term fellowship. He unraveled the basic mechanism of RAG1/2 mediated V(D)J recombination, which generates the antigen receptor diversity in B and T cells. For this work he received the biennial prize of the Netherlands Society of Biochemistry and Molecular Biology (NVBMB) in 1997. In 1996 he moved to the Erasmus University Rotterdam (now Erasmus MC), Department of Molecular Genetics. He received a KNAW fellowship to establish his own line of research here. Since then he received research funding from the Netherlands Scientific Organization (NWO), the Netherlands Cancer Foundation (KWF), the Association for International Cancer Research (AICR) and the European Union.
He studied many aspects of DNA double strand break repair, with emphasis on the non-homologous end-joining pathway. More recently, he concentrated on studying the effects of chemotherapy, radiotherapy and targeted therapy in various types of cancer tissues using ex vivo culture methods. He authored approximately 100 peer-reviewed papers.
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