Flow Chemistry Congress Agenda

Registration

Recent Advances in Synthetic Photochemistry in Microflow Systems
Tim Jamison, Professor, Massachusetts Institute of Technology, United States of America

In the past few years photochemistry has played an increasingly important role in continuous flow organic synthesis. Case studies of our recent investigations in this area, with an emphasis on catalysis and multi-step synthesis, will be presented.

Enabling Chemical Synthesis through Flow Chemistry
Paul Richardson, Senior Principal Scientist, Pfizer Worldwide Research and Development, United States of America

This talk focuses on recent Flow Chemistry carried out at Pfizer-La Jolla. In particular, the continuing development of the Accendo Flow Reactor, and the transition from Medicinal to Process Chemistry of chemistry amenable to Flow will be highlighted.

Coffee and Networking in the Exhibition Hall

Some Like it Hot - Scaling Microwave Chemistry Using High-Temperature/Pressure Flow Reactors
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria

Microwave chemistry has now become a standard technique in most academic and industrial labs to run batch reactions on a laboratory scale. In this talk the translation of microwave batch chemistry on the mg or g scale to the kg scale and beyond using conventionally heated high-temperature/high pressure flow reactors will be discussed.

Technology Spotlight:
Enhanced Development and Control of Continuous Processes
Dominique Hebrault, Senior Technology and Application Consultant, Mettler Toledo AutoChem Inc

One of the main analytical challenges for continuous chemistry is real-time inline monitoring for enhanced understanding and control of reactions, especially when dealing with multistep sequences. This presentation will discuss ReactIR™ in situ IR spectroscopy and the latest flow chemistry technology available as well as case studies showing how this technology monitors and provides reaction feedback on control parameters for immediate understanding and optimization of processes.

Lunch and Networking in Exhibition Hall

Free Workshop
Flow Chemistry Workshop
Billy Bullock, Regional Manager

Poster Viewing

Flow Chemistry as an Enabling Technology for Synthesis: Organic Chemistry and Beyond
Nicholas Leadbeater, Associate Professor, University of Connecticut, United States of America

The use of flow chemistry as an enabling technology for synthesis in our laboratory will be discussed. Topics will include: transitioning microwave-mediated synthesis to conventionally-heated flow, meso-scale synthetic transformations using reactive gases, organometallic synthesis, methods to resolve solubility issues in flow, and recent unpublished developments.

Coffee and Networking in Exhibition Hall

Optimizing Acid-Catalyzed Reactions with a Continuous Flow Microreactor
Paul Floreancig, Associate Professor, University of Pittsburg, United States of America

This talk will describe the construction of a simple flow reactor with online detection capacity and its application to mechanistic analysis and optimization of acid-catalyzed reactions.

Exothermic and Hazardous Chemistry in Continuous Flow
Cara Brocklehurst, Investigator III, Novartis Pharma AG, Switzerland

This talk will demonstrate the use of a R2C/R4 Vapourtec machine in the scale up of a range of challenging reactions including a troublesome nitration involving a potentially explosive mixture of acetic and fuming nitric acids.

End of Day One

Proven Route to Production Scale Flow Chemistry
Daniel Unge, Application Manager, Alfa Laval Tumba, Sweden

Scale-up of flow chemistry has been performed and are presented to give guidance on how to maintain the benefits from the lab to full production. An organometallic synthesis / reduction is used as chemistry example.

Coffee and Networking in Exhibition Hall

How to Transfer Flow Chemistry from Lab to Manufacturing
Dirk Kirschneck, Managing Director, Microinnova Engineering GmbH, Austria

This presentation demonstrates the procedure to transfer Flow Chemistry from lab to manufacturing scale and shows the different options on manufacturing scale.

Development and Scale-up of a Continuous Process: From Concept to Implementation
Timothy White, Research Scientist, Lilly, United States of America

The development of a synthetic route to tasisulam sodium (5-bromo-thiophene-2-sulfonic acid 2, 4-dichlorobenzoylamide sodium salt) utilizing continuous Schotten-Baumann reaction conditions is presented. Batch development, continuous proof of concept, 50 g/day lab scale demonstration and 5 kg/day commercial scale runs will be described.

Jennifer Groh, Research Scientist, Lilly
Jennifer Groh, Research Scientist, Lilly, United States of America

The development of multiple continuous Grignard chemistry processes at 250mL scale will be discussed including: safety advantages, continuous stirred tank reactors (CSTR) setup, magnesium conservation, maintaining sequestered solids, monitoring mass transfer, and automation challenges.

Technology Spotlight:
Microreaction Plants for Handling of Aggressive Chemicals
Andreas Freitag, Product Manager, Mikroglas Chemtech

The concept of a modular microchemical plant will be explained which can handle aggressive chemicals to carry out a broad range of chemical reactions under controlled conditions.

Lunch and Networking in Exhibition Hall

Poster Viewing

It Works In The Lab: So Now What?
David Ager, Principal Scientist, DSM Pharma Chemicals, United States of America

The use of flow chemistry and careful design of experiments, can allow for the rapid and predictable scale up of reactions. Three examples where this has been accomplished for production scale reactions are presented.

Microfluidic Fabrication of Polymer Fibers
Peter Howell, Postdoc, Naval Research Laboratory, United States of America

Microfluidic chips are used to shape flows of polymerizable material, which is then hardened into fibers of defined shape and size.

Coffee and Networking in Exhibition Hall

The Incorporation of a Continuous Process in the Manufacturing of Active Pharmaceutical Ingredients
Olivier Dapremont, Director, American Pacific Corporation, United States of America

AFC is evaluating how a continuous process step in the manufacturing process of an API can be designed and implemented in a regulatory environment. Examples of continuous processes implemented at commercial scale will be described with emphasis on quality and process developments.

Close of Conference