Biosensors, Microfluidics and Lab-on-a-Chip Technologies Agenda

Registration

A Microfluidic Culturing and Real Time Monitoring Systems Using Diffusive Nutrition Distribution
Winnie Svendsen, Professor, Technical University of Denmark, Denmark

A microfluidic platform separating nutrient perfusion from the culturing site, thus utilizing diffusive nutrient delivery, has been developed and tested on several cell types and brain slices. The results and future potential of this platform will be presented and discussed.

Microfluidic Platforms Incorporating Design-For-Manufacture and Scale-Up of Production for De-Risking Commercialisation
Jens Ducree, Professor of Microsystems, Dublin City University, Ireland

The presentation outlines the adoption of the platform based concept to microfluidic “Lab-on-a-Disc” systems developed in the recently founded Fraunhofer Project Centre for Embedded Bioanalytical Systems at Dublin City University.

Coffee & Networking in Exhibition Hall

Microfluidic Single Cell Sequencing
Yanyi Huang, Professor, Peking University, China

Microfluidic technologies can greatly facilitate the research at the single cell level, especially the genomic sequencing of single cells with greatly improved sensitivity, reproducibility, and accuracy.

Status of the Microfluidics Industry
Benjamin Roussel, Business Unit Manager of the Microfluidic & Medical Technologies (MedTech), Yole Développement

This year, KnowMade and Yole joined forces to get a comprehensive analysis of the microfluidics world in terms of market, technology and IP. This talk will present some of the results from their analysis to explain how and why microfluidic technologies are increasingly used, for which benefits. Benjamin Roussel will share his view of the strong maturation of the microfluidics industry, important strategic moves, race for molecular diagnostics, and IP strategy of main players.

Microfluidic Devices for Cryomicroscopy of Cells and Soft Materials
Thomas Burg, Group Leader, Max Planck Institute for Biophysical Chemistry, Germany

Light and electron microscopy can reveal amazing details of cell function and disease with nanometer resolution in single cells. Here I present a new microfluidic technology for imaging fast cellular dynamics by correlating live-cell imaging, cryo-light microscopy and electron microscopy.

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Free Workshop
Translating Customers Ideas into Microstructured Smart Polymer Parts Workshop
Iris Bergmair, Head of Sales & Business Development

Technology Spotlight:
Need for Surface Tension Preparation for Microfluidic Devices
Ken Sautter, Director of Technology Development, Yield Engineering Systems, Inc.

This presentation will discuss the need for surface tension modification for successful microfluidic devices. Silane vapor phase deposition is the preferred method for coating surfaces, as the process environment can be tightly controlled, yielding repeatable, stable results. A process will be discussed offering multiple gas and plasma mode preparation plus multiple chemical reactants for vapor phase deposition, in order to prepare for optimum surface conditions.

Centrifugal Step Emulsification Allows Miniaturized Digital Droplet-RPA,-LAMP and -PCR on the Centrifugal Microfluidic Platform
Felix von Stetten, Associate Director, Hahn-Schickard

A novel unit operation, designated as centrifugal step emulsification, enables droplet generation, DNA amplification and fluorescence detection within one single cavity. Results for absolute quantification of DNA by digital amplification are in good agreement with those obtained by a commercial dPCR system.

Coffee & Networking in Exhibition Hall

Microfluidics and Magnetic Particles for Cancer Clinical Research
Stephanie Descroix, Research Scientist, Institut Curie, France

A Conceptually New Photomicroreactor Design for Energy-efficient Solar Photochemistry
Timothy Noël, Professor, University of Amsterdam, Netherlands

We will present our results concerning a novel device integrating the luminescent solar concentrator (LSC) concept with photomicroreactors, allowing the direct use of solar light in photochemistry without the need for any intermediate energy conversion. This leaf-inspired photomicroreactor based on fluorescent dye-embedded polydimethylsiloxane collects sunlight, focuses the energy to a narrow wavelength region, and then transports that energy to embedded microchannels where the flowing reactants are converted.

Rapid Prototyping in Microfluidics: New Perspective by New Materials
Bastian Rapp, Principal Investigator and Head of NeptunLab, Karlsruhe Institute of Technology, Germany

This talk will highlight important improvements in additive manufacturing technology and materials for microfluidics.

Drinks Reception in Exhibition Hall

End of Day One

Translation of Microfluidic Technologies from the Laboratory to the Field
Joan Bienvenue, Executive Director, Applied Research Institute, University of Virginia, United States of America

This presentation will discuss commercialization of microfluidic technologies, the challenges and opportunities of taking lab-on-a-chip discoveries out of the laboratory and to applied use.

New Approaches for Medical Diagnosis and Therapy Using Microfluidic Devices
Manabu Tokeshi, Professor, Hokkaido University, Japan

This presentation reports the development of a new platform of immunoassay device for detection of brain tumor. Using this devices, we succeeded in detection of grade II and III gliomas from patients within 15 min.

Coffee & Networking in Exhibition Hall

Acoustic Force Spectroscopy: Using Sound to Investigate Molecules and Cells
Gijs Wuite, Assistant Professor, Vrije Universiteit, Netherlands

Acoustic force spectroscopy (AFS) is a novel technique that makes use of an acoustic standing wave in a microfluidic chip to apply forces on cells or micron-sized beads tethered to molecules in order to study their mechanical properties

Label-Free Particle Sorting - Innovative Ways to Fractionate Cells Based on their Innate Properties
Jonas Tegenfeldt, Professor, Lund University, Sweden

Label-free sorting uses the inherent properties of the particles to divide them into different fractions. We will present results on sorting of cells and particles based not only on size but also shape, deformability, density and dielectric properties.

Ultrafast, Low-resource, Cost-effective Rapid-prototyping and Assembly Techniques for Accelerated Translation of Lab-On-Chip Microfluidic Devices: Novel and Revisited Concepts
Maiwenn Kersaudy-Kerhoas, Professor of Microfluidic Engineering, Heriot-Watt University, United Kingdom

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Free Workshop
The Fast Tracking Medical Diagnostics and Biosensor Technologies to the Market Workshop
Martin Peacock, Director

Cell Analysis Beyond Vision Using CAN-Spectroscopy
Jonas Lehmann, Co-Founder & Managing Director, Venneos GmbH

Technology Spotlight:
Improving Peptide-Multiplexing Technology for Lab-On-Chip Autoantibody Based Diagnostics
Andreas Weinhaeusel, Senior Scientist, Austrian Institute of Technology GmbH

Detection of (tumor) autoantibodies present in patients’ blood against self-antigens, or aberrantly expressed proteins of tumor cells, presenting then tumor-associated antigens (TAAs) to the immune-system has a high potential for diagnostics. We have setup immunomics biomarker-discovery using protein- and peptide-microarrays as well as targeted multiplexed technologies for validation of these markers.

Lab-on-a-Chip with Incorporated Microarrays for the Detection of AMRs
Harald Peter, Research Scientist, Fraunhofer Institute for Cell Therapy and Immunology IZI-BB, Germany

Lab-on-a-chip multiplex assays allow a rapid identification of multiple parameters in an automated manner. Here we describe a lab-based preparation followed by a rapid and fully automated DNA microarray hybridization and readout in less than 10 minutes using the Fraunhofer in vitro diagnostics (IVD) platform to enable rapid identification of bacterial species and detection of antibiotic resistance. The use of DNA microarrays allows a fast adaptation of new biomarkers enabling the identification of different genes as well as single-nucleotide-polymorphisms (SNPs) within these genes. In this protocol we describe a DNA microarray developed for identification of Staphylococcus aureus and the mecA resistance gene.

Coffee & Networking in Exhibition Hall

Capillary-Based Microfluidics: from Concepts to Chips
Emmanuel Delamarche, Manager Precision Diagnostics, IBM Research - Zürich, Switzerland

This presentation describes the development of microfluidic functional elements for capillary-driven microfluidic chips. These chips can be used for immunoassays and connected to a smartphone for monitoring flow with sub-nanoliter precision.

Nanoplasmonic Biosensors: a Search for the Optimum Balance Between Optical Performance and Analyte Transport
Nicholas Scott Lynn, Research Scientist, The Institute of Photonics and Electronics of the Czech Academy of Sciences (IPE), Czech Republic

This presentation describes the development of microfluidic nanoplasmonic biosensors composed of arrays of metal nanoparticles, specifically focusing on the balance between optical performance (in terms of RI sensitivity) and analyte transport (in terms of the rate of analyte capture).

Close of Conference