Other Track AgendasEnabling Genomic Technologies | Screening Asia |
Thursday, 11 September 201408:00 | Registration | |
Gene & Pathway Discovery with RNAi |
| | 09:00 |  | Keynote Presentation Novel and highly selective molecular tools to monitor and modulate activity of oncogenic b-catenin in Wnt-associated cancers
Ramanuj Gupta, Senior Investigator, Genome Institute of Singapore, A*STAR, NYU Cancer Institute , Singapore
The Wnt/b-catenin pathway is one of a core set of evolutionarily conserved signaling pathways that regulate many aspects of metazoan development. Inappropriate activation of the Wnt/b-catenin pathway has been associated with tumorigenesis of the liver, colon, breast and skin.
Here we describe our recent effort at screening for novel and specific small molecule as well as peptido-mimetic inhibitors of oncogenic b-catenin that are being developed as novel therapeutic and molecular tools to study the function of this important pathway in the context of normal development, regeneration, and cancer. |
| 10:00 | Exploring the regulation of protein glycosylation using RNAi screening
Frederic Bard, Assistant Professor, Institute for Molecular and Cell Biology, Singapore
| 10:30 | Coffee Break and Networking in Exhibition Area | 11:15 | A functional siRNA screening approach to discover therapeutic candidates for the treatment of Diamond-Blackfan anaemia and other rare bone marrow failure syndromes
Amee George, Research Officer, Peter MacCallum Cancer Centre, Australia
| 11:45 | Exploring Immune Signaling Systems with High Throughput, High Content Screening.
Iain Fraser, Head Laboratory of Systems Biology, National Institutes of Health, United States of America
| 12:15 | Lunch Break and Poster Session | |
miRNAs, long non-coding RNAs, & epigenetic control |
| | 13:45 | Using ncRNAs to identify cancer cell vulnerabilities
Alexander Pertsemlidis, Associate Professor, The University of Texas Health Science Center at San Antonio, United States of America
| 14:15 | Lacer - robust and accurate base quality score recalibration for all organisms
Swaine Chen, Assistant Professor, National University of Singapore, Singapore
| 14:45 | Coffee Break and Networking in Exhibition Area | 15:15 | Targeting RNA Structures by Triplex Formation
Gang Chen, Assistant Professor, Nanyang Technological University , Singapore
| 15:45 | Functional evaluation for the utilisation of recognised oncogenic miRNAs as neuroblastoma chemoresistance biomarkers
Duncan Ayers, Post Doctoral Researcher, University of Malta / University of Manchester, Malta
This project focuses on exploring possible correlations between dys-regulated expression of miRNAs (recognised to be oncogenic in multiple cancer models) and neuroblastoma chemoresistance properties within representative cell lines. | 16:15 | Tour of the GIS High-throughput Cell Biology Centre (GIS-HTCB) | 17:30 | End of Day One |
Friday, 12 September 201408:00 | Registration | |
Genome Editing Tools |
| | 09:00 |  | Keynote Presentation Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
Kosuke Yusa, , Welcome Trust Sanger Institute, United Kingdom
The CRISPR-Cas system is an emerging new technology for genome editing. Its flexibility and scalability enable us to use this system as a functional genomics tool. We have constructed genome-wide lentiviral CRISPR libraries and conducted loss-of-function screens to identify genes that modulate cellular susceptibility to cytotoxic reagents such as a toxin. Our results highlight a wide applicability of the CRISPR-Cas9 system. |
| 10:00 | Genomic Tools for the Functional Dissection of RNA Editing
Meng How Tan, Research Scientist / Assistant Professor, Genome Institute of Singapore, Singapore
| 10:30 | Coffee Break and Networking in Exhibition Area | 11:15 |  Technology Spotlight:
Directed Protein Evolution in a Single Step
Chee Yang-Lee , Field Applications Scientist, Agilent
We have developed a novel method for the creation of rationally designed protein variants by combining high fidelity oligonucleotide libraries with the QuikChange method.
QuikChange HT allows rapid resolution of structural and functional questions by creating libraries of rationally designed mutants. Applications such as alanine scanning, Site Saturation Scanning and targeted Combinatorial Mutagenesis can now be done routinely as both the creation of mutants libraries and the screening efforts are minimized.
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Genomic Big Data Sets & Bioinformatic Tools |
| | 11:30 | Technology Spotlight:
Bioinformatics Tools for All: Free Software Tools for Designing Assays and NGS Data Analysis
Chee Yang-Lee , Field Applications Scientist, Agilent
| 11:45 | A Journey through Phenotype and Genotype Relationships
Pauline Ng, Group Leader, Genome Institute of Singapore, Singapore
| 12:15 | Lunch Break and Poster Session | 13:45 | POLARIS – A translational bridge for disease biomarkers and diagnostic technologies
Sophie Ran Wang, , Genome Institute of Singapore (GIS), Singapore
| 14:15 | Big Data Processing Environment and Mathematical Modeling for Psychiatric Diagnosis
Kazuo Ishii, Professor, Tokyo University of Agriculture And Technology, Japan
A big data processing environment was constructed to develop a psychiatric diagnosis system. And large-scale data analysis with genomic data, including quantitative PCR, microarray and next generation sequencing technologies, were performed. | 14:45 | Coffee Break and Networking in Exhibition Area | 15:30 | PANEL DISCUSSION - Pros and Cons - CRISPR vs. RNAi / Is CRISPR going to wipe out RNAi? / 2D vs. 3D - What is the best model? / Cell-Based Assays vs. Cell-Free Assays | 17:00 | Closing Reception |
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Add to Calendar ▼2014-09-11 00:00:002014-09-12 00:00:00Europe/LondonEnabling Genomic TechnologiesSELECTBIOenquiries@selectbiosciences.com
