Microarray World Congress Agenda

Registration

Biomarker Discovery: SOMAscan and Clinical Data
Larry Gold, Chief Executive Officer/Chairman, SomaLogic, United States of America

Technology Spotlight:
The Influence of Drop Drying on Chemical Reactivity: The Specific Case of Immobilization of Oligonucleotides on Microarray Surfaces
Jens Sobek, Research Scientist, University of Zurich


Drop drying is a key factor in a wide range of technical applications, including spotted microarrays. The applied nL liquid volume provides specific reaction conditions for the immobilization of molecules on a chemically modified surface. I report on the influence of nL and µL liquid drop volumes on the process of molecule immobilization and compare the results obtained with the situation in liquid solution. The data reveal a fundamental relationship between drop drying and surface chemistry on the one hand, and the selectivity of oligonucleotides, our model system, reacting with the surface on the other.

Coffee Break and Networking in Exhibition Hall

Dynamic Multi-Analyte Testing Technology for Accelerated Biomarker Measurement
Patrick van den Bogaard, Director, Biocartis, Switzerland

With the integration of semiconductor and microfluidics technologies we have developed a biomarker analysis platform that provides reproducible and high quality multiplex detection of proteins and nucleic acids in a very simple and short workflow. 

An Integrated System Using Peptide Arrays to Assess Kinase and Nuclear Receptor Activities in Clinical Samples for Biomarker Development
Bertrand Jordan, Advisor, CoReBio PACA, France

A system developed around peptide microarrays allows real-time measurement of phosphorylations or interactions, with sophisticated software for data acquisition and interpretation. It is applied to kinase activity profiling and nuclear receptor-coregulator interactions, in order to develop biomarkers and diagnostic applications.

Lunch Break and Networking in Exhibition Hall

Poster Viewing Session

Protein and Peptide Arrays for Immune Studies
Paul Utz, Associate Professor, Stanford University School of Medicine, United States of America

Effect of Feature Selection and Sample Size on the Evaluation Genomic Classifiers
Sitan Yang, Research Assistant, Johns Hopkins University, United States of America

We investigate the predictive performance of a representative set of genomic classifiers under conditions of different feature selection methods and training sample sizes. We analyze these effects using MAQC-II breast cancer as well as simulated datasets.     

Coffee Break and Networking in Exhibition Hall

Skinomics - The Use of Microarrays in Dermatology and Skin Biology
Miroslav Blumenberg, Associate Professor, NYU Langone Medical Center, United States of America

Due to accessibility skin and dermatology were among the earliest objects for microarray studies. Noninvasive skin sampling targeted melanomas; additionally, carcinomas, psoriasis, wound-healing, etc. have been analyzed. Recently, using microarrays identified genes specific for epidermal stem cells and those changing during keratinization.

Validation of Tissue Biomarkers
Stephen Hewitt, Clinical Investigator, National Institute of Health, United States of America

A data-driven review of the failure and means of improving tissue-based biomarker validation. 

Drinks Reception and Networking in Exhibition Hall

Exploring the Global Genomic Landscape of Enteric Pathogens Using DNA Microarray Technology
Scott Jackson, Principal Investigator/Molecular Epidemiologist, United States Food and Drug Administration, United States of America

Coffee Break and Networking in Exhibition Hall

Self-Reporting Microarray Platforms that Use Molecular Beacon Probes
Salvatore Marras, Assistant Professor, University of Medicine and Dentistry of New Jersey, United States of America

Molecular beacon probes, which generate a fluorescence signal only when they bind to their target, enable the development of self-reporting DNA microarrays.  This presentation will show how unlabelled nucleic acids can be detected using arrayed molecular beacons.

High-Throughput Screening of Protein-Membrane and Drug-Membrane Interactions Using Lipid Microarrays Created with a Continuous Flow Microspotter™
John Conboy, Professor, University of Utah, United States of America

Micropatterned lipid bilayer arrays (MLBAs) using a Continuous Flow Microspotter™ (CFM, Wasatch Microfluidics) are used to measure protein-membrane and drug-membrane interactions in a high-throughput manner.

Technology Spotlight:
Nanoscale Spotting: From Proof-of-Concept to Manufacturing Scale Production Workshop
Claude Dufresne, Scientific Business Development Manager, Scienion AG

Lunch Break and Networking in Exhibition Hall

Poster Viewing Session

Lipid Array Characterization of Multiple Sclerosis
Jeremy Sokolove, Senior Investigator, Stanford University, United States of America

Cell Lysate Arrays for High-Throughput Screening
Ines Block, PostDoctoral Researcher, Institute for Molecular Medicine (Denmark), Denmark

Coffee Break and Networking in Exhibition Hall

Microarray-based High Throughput Sceening of Sol-Gel-Derived Materials for Preparation of Protein and Cell Microarrays
John Brennan, Professor and Director, Biointerfaces Institute, McMaster University, Canada

A microarray-based screening method was used to identify optimal sol-gel based materials to fabricate protein and cell microarrays. The use of such microarrays for small molecule screening and multiplexed biosensing will be described.

Close of Conference