Other Track AgendasBioDetection and BioSensors Summit 2019 | BioEngineering Summit 2019 |
Monday, 1 April 201908:00 | Day 1 of the Event is the BioEngineering Track |
Tuesday, 2 April 201908:00 | Morning Coffee, Pastries and Networking | 09:00 |  | Keynote Presentation Wearable Electrochemical Sensors: Toward Labs on the Skin or in the Mouth
Joseph Wang, Chair of Nanoengineering, SAIC Endowed Professor, Director at Center of Wearable Sensors, University of California-San Diego, United States of America
Wearable sensors have received a major recent attention owing to their considerable promise for monitoring the wearer’s health and wellness. The medical interest for wearable systems arises from the need for monitoring patients over long periods of time. These devices have the potential to continuously collect vital health information from a person’s body and provide this information to them or their healthcare provider in a timely fashion. Such sensing platforms provide new avenues to continuously and non-invasively monitor individuals and can thus tender crucial real-time information regarding a wearer’s health. This presentation will discuss recent developments in the field of wearable electrochemical sensors integrated directly on the epidermis or within the mouth for various non-invasive biomedical monitoring applications. Particular attention will be given to non-invasive monitoring of metabolites and electrolytes using flexible amperometric and potentiometric sensors, respectively, along with related materials and integration considerations. The preparation and characterization of such wearable electrochemical sensors will be described, along with their current status and future prospects and challenges. |
| 09:45 | Soft Electronics For Noninvasive Healthcare: From the Skin to Below the Skin
Sheng Xu, Assistant Professor, University of California, San Diego, United States of America
Soft electronic devices that can acquire vital signs from the human body
represent an important trend for healthcare. Combined strategies of
materials design and advanced microfabrication allow the integration of a
variety of components and devices on a stretchable platform, resulting
in systems with minimal constraints on the human body. We have
demonstrated a skin-mounted multichannel health monitor that can sense
local field potentials, temperature, strain, acceleration, and body
orientation. Integrating ultrasonic transducers on this stretchable
platform adds a third dimension to the detection range by launching
ultrasound waves that reach well underneath the skin. The ultrasound
waves allow capturing a wide range of dynamic events in deep tissues
such as blood pressure and blood flow waveforms in central arteries and
veins. This technology holds profound implications for continuous and
noninvasive sensing, diagnosis, and treatment of chronic diseases. | 10:15 | Small Sensors Go Big: Towards High-Resolution Monitoring of Industrial Fermentations
Helena Junicke, Marie-Curie Researcher, Technical University of Denmark, Denmark
Miniaturized sensors provide new opportunities for industrial
fermentation control. In this frequently overlooked application, sensors
allow for an improved spatial surveillance of production units, leading
to increased performance and lower risk of failure. | 10:45 | Morning Coffee Break | 11:30 | Phage Display and Directed Molecular Evolution: The Nobel Prize and Beyond. Impact on Material Engineering and Biosensor Development
Valery Petrenko, Professor, Auburn University, United States of America
Development of phage engineering technology led to construction of a novel type of phage display libraries—collections of nanofiber materials with diverse molecular landscapes accommodated on the surface of phage particles. These new nanomaterials, called “landscape phage,” serve as a huge resource of diagnostic/detection probes and versatile construction materials for preparation of phage-functionalized biosensors. Landscape-phage-derived probes interact with biological threat agents and generate detectable signals as a part of robust and inexpensive molecular recognition interfaces introduced in mobile detection devices. The use of landscape-phage-based interfaces may greatly improve the sensitivity, selectivity, robustness, and longevity of these devices. My talk aims to attract the attention of chemical scientists and bioengineers seeking to develop functionalized materials and use them in different areas of bioscience, medicine, and engineering. | 12:15 | Sensors for Biosensors: Efficient Strategies Towards Successful Screening and Commercialization
Daria Semenova, Researcher, Technical University of Denmark, Denmark
Novel strategies towards biosensor design optimization based on
combining the results of multi-analytical studies together with the
mathematical modelling should be integrated. Moreover, the development
of the database platforms for the available sensing technologies should
be promoted for further progress in biosensorics. | 12:45 | Networking Lunch | 14:00 |  | Keynote Presentation Feedback Control of Plasma Drug Levels Supported by Continuous In-Vivo Measurements
Netz Arroyo, Assistant Professor of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, United States of America
Personalized drug therapy seeks to tailor treatment to the individual, taking into consideration each person’s unique genotype and metabolism to determine a dose that maximizes drug efficacy and avoids toxicity. Realizing this goal has been extremely challenging, however, for two main reasons. First, it is difficult to determine the optimal drug dose for each patient due to our limited understanding of pharmacogenetics and physiology. Second, even the most sophisticated drug delivery approaches fail to account for hour-to-hour fluctuations in an individual’s metabolism driven by changes in health status, diet or drug interactions. Thus, there remains a pressing need for technologies supporting the real-time, in-vivo monitoring of drugs that would enable patient-specific, metabolism-responsive dosing. In response to this need, our laboratory pursues the development of reagentless sensing approaches that support continuous measurement in the body. During this talk, I will describe an electrochemical approach that relies on DNA aptamers to perform real-time monitoring of small molecule targets, and the use of this approach to study pharmacokinetic changes in rats that originate from biological and metabolic variability. |
| 14:45 | Highly-Refractive Barium Titanate Microspheres For Low-Cost Resolution Enhancement In Optical Imaging of Living Micro-Organisms
Daniel Migliozzi, Researcher, Ecole Polytechnique Federale de Lausanne, Switzerland
In this work, we performed a systematic study of the increased resolution mediated by highly-refractive microspheres when imaging micro-structures and micro-objects, and we applied this results to the imaging of micro-organisms in aqueous media. | 15:15 | Novel Split Trehalase as a Versatile Detection Assay for a Wide Range of Analytes
Marija Drikic, Researcher, University of Calgary, Canada
Biosensors have a potential to become universal diagnostic devices available Anywhere, Anytime, to Anyone and for the detection of any analyte (anything). Although different studies over the years aimed to develop such a diagnostic device, until today none have managed to meet all 4 criteria and enter into clinical practice. The most successful class of biosensors currently on the market is the glucometer used to monitor blood glucose. Performance in clinical samples, sensitivity and specificity have largely been optimized, measuring devices have been miniaturized and production costs optimized. The aim of our study was to develop a novel technology that uses the existing biosensor but increases the type and number of analytes that can be detected. We report the periplasmic trehalase of E. coli as a novel split enzyme reporter capable of converting various analytes into glucose. We proved that conditional complementation of the trehalase fragments leading to trehalose hydrolysis and glucose production, can be used to detect antibodies, bacterial cells, small molecules, but also protein-protein interaction and protein aggregation. We demonstrated retention of activity of split TreA in undiluted clinical samples. Furthermore, we applied this technology to develop and validate a diagnostic tool for efficient quantification of the total amount of immunoglobulins in bovine colostrum and serum. We explored its applicability do develop detection assays in different animal species. In conclusion, the resulting trehalase-based biosensor assay offers a versatile and convenient method for point-of-care applications as it does requires minimal sample preparation and can be integrated with existing glucometers or sensors. | 16:00 | Closing Coffee Break |
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Add to Calendar ▼2019-04-01 00:00:002019-04-02 00:00:00Europe/LondonBioDetection and BioSensors Summit 2019SELECTBIOenquiries@selectbiosciences.com
