Abstract

Advance Techniques in Liquid Chromatogram and Mass Spectrometer (LCMS)

Mayuri Gandhi, Research Scientist, Indian Institute of Technology, Bombay

Developing instrumentation and technologies are will be important aspects of future mass spectrometry techniques and its expansion to important new applications. An extremely important example is the need for LC/MS bioanalysis (quantitation) of biologics (ADC?s, large molecules,RNA, etc.) in biological samples employing both bottom up and top down methods. HRAMS coupled with “protein friendly” chromatography will significantly expand our present analytical capabilities. Ion mobility spectrometry (IMS) and transportable mass spectrometers could lead to point-of-care applications and other far reaching applications of mass spectrometry beyond what we are doing today. The future is very exciting! Sample preparation, Advanced separation techniques, Ionization techniques for MS , Mass Analyzers, Imaging and profiling by MS, High resolution MS, Miniaturization in MS, Synergistic Integration are different part for the advancement in techniques.