Abstract

Accelerated C–H Activation Chemistry in Flow Microreactors

Timothy Noël, Professor, University of Amsterdam

The use of microfluidic devices has recently attracted much attention from the pharmaceutical industry. This is due to the fact that these devices provide several advantages for chemical synthesis, such as enhanced heat- and mass-transfer, precise control over residence (reaction) time and scalability. In recent years, our group has focused on the development of more efficient C–H activation to establish carbon-carbon bonds, including the alkenylation and arylation of indoles and cross-dehydrogenative coupling reactions. This lecture will describe our results in this field and will provide insight information about the discovery process and the different parameters that led to success.