Abstract

Applications of Fully Integrated Active and Passive Flow Control in the Organ-on-Chip, Analytical and Diagnostics Field

Marko Blom, Chief Technical Officer, Micronit Microtechnologies

We will present various applications and examples in the organ-on-chip, analytical and diagnostics field relying on fully integrated active and passive, capillary driven flow control. Active valving fabrication strategies will be shown which do not require adhesives for the integration of materials relevant to the above mentioned fields.
The applications will range from accurate dosing, distribution and dispensing for cell culturing and Organ-On-Chip (OOC) applications to examples of sequential capillary flow in polymeric devices controlled by low-power electrical triggers realized using integrated electrodes. Specifically for the OOC field we have developed scalable Design-For-Manufacturability (DFM) concepts for such OOC applications, varying from resealable devices to fully integrated microtiter plate format culturing tools.  The concepts are tested and validated in the field by end-users. Here, we demonstrate their use and applicability as versatile, flexible and enabling R&D tools for prototyping and (further) development of OOC applications.