Abstract

Present (and Future) Uses for Stem Cells Derived Preparations in Drug Discovery and Toxicity Testing

Gary Gintant, Research Fellow, Abbvie

The advent of human pluripotent stem cells a decade ago sparked visions of novel screening approaches for drug safety and efficacy, narrowing the translational gap between traditional preclinical and clinical studies,  and defining  a new “proclinical space” where human derived preparations are used  in preclinical assays.  Not unlike other novel (and potentially disruptive) technologies, limitations learned along the way have provided new challenges for both the biology and technologies necessary for confident and efficient screening efforts.  This presentation will highlight promising present and future applications for stem cell derived preparations, focusing on prospects for achieving translational success of new drug candidates.