Abstract

Modular Microfluidics For Automating Biochemical Workflows

Noah Malmstadt, Professor of Chemical Engineering and Materials Science, University of Southern California

Traditional approaches to microfluidic fabrication and modeling have relied on custom fabrication work flows that often focus on limited runs of one-off devices. This has led to a high cost that has limited the adaption of microfluidic systems for real-world applications. We have been developing an alternate approach to microfluidic fabrication that focuses on manufacturing modular elements which are then assembled into microfluidic analytical systems. Functional components are integrated into these elements; the structures are printed to directly accommodate off-the-shelf components including photodiodes, heaters, sensors, and fiber optic fittings. We have demonstrated the utility of this approach by assembling systems capable of performing automated biomolecular workflows, including immunosorbent assays, agglomeration assays, and complex multi-step protein and oligonucleotide handling.