Clogging-Free Continuous Operation with Whole Blood in a Microfluidic Radial Pillar Device (RAPID)
Shilpi Pandey, Research Scholar, IIT Bombay
Physical
properties of cells, such as, shape, deformability, etc. have recently generated
a lot of interest as potential markers for different diseases. For example, the
red blood cells (RBCs) become stiffer when infected by malaria parasites.
Normally biconcave and deformable red blood cells become both sickle-shaped and
stiffer in sickle cell anemia leading to blockage of blood vessels. In our lab
we are using microfluidic technology to probe cell size, shape and
deformability to diagnose different blood-related disorders. In this talk I
will briefly discuss about enriching the platelet population in blood using the
variation in size and deformability of different blood cells.
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