Abstract

Merging Organ-on-a-Chip with Organoids: The Best of Two Worlds?

Paul Vulto, Managing Director, MIMETAS

Organ-on-a-Chip and organoids are two fields of development that are rapidly redefining  cell culture biology in the 21st century. Organ-on-a-Chip technology has demonstrated how microengineering technology can add aspects such as perfusion flow, patterning of tissues, precise control over gradients and application of mechanical strain to tissue culture. Organoid protocols have been carefully optimized to maintain the stem cell niche in developing and adult tissues, while at the same time permitting cell proliferation and differentiation.

In this lecture, I will show latest progress at MIMETAS integrating organoid protocols and Organ-on-a-Chip technology. I will show a range of tissue models comprising complex co-cultures, in a perfused system using state of the art stem cell and organoid protocols. Following this presentation, it will become clear that the two fields are merging together to aid cell culture of the 21st century.