Abstract

Adding Structure to High Throughput hiPSC-derived Cardiac and Neuronal Models for Improved Physiological Relevance and Performance

Fabian Zanella, Director of Research and Development, StemoniX Inc.

Here we provide case studies how on induced pluripotent stem cell (hiPSC)-based platforms structurally engineered for greater physiological relevance can elevate performance in drug discovery applications. microBrain^® 3D comprises cortical neural spheroids that feature high functionality with robust spontaneous activity and expected responses to established neuromodulators. microHeart^® allows cardiomyocytes to adopt cell geometries and intercellular organization that resemble native heart tissue, translating into to differential pharmacological response to known cardioactive compounds.