Abstract

Low Cost Diagnostics For Global Health – Improving R&D Processes, Manufacturability, and Assay Performance

Bernhard Weigl, Director, Center for In-Vitro Diagnostics, Intellectual Ventures/Global Good

At Global Good we focus on in-vitro diagnostics for low resource settings and develop ultra-high sensitivity lateral flow assays, phage-based rapid bacteria viability assays, disposable cartridge highly multiplexed NAAT assays, and simple very low cost medium sensitivity nucleic acid assays, and low cost highly multiplexed digital formats. For our lateral flow assay work we have developed a high throughput array-based empirical optimization system for lateral flow assays that speeds up R&D and results in better performing assays. We will demonstrate the results of this new optimization approach for two new malaria lateral flow assays. We will also provide an overview over new assay R&D in the tuberculosis field on NAAT, phage, and digital platforms.