Abstract

Image-Activated Cell Sorting and Beyond

Keisuke Goda, Professor of Physical Chemistry, University of Tokyo

I introduce a newly developed technology known as “Image-Activated Cell Sorting” [Cell 175, 266 (2018)] that realizes real-time image-based intelligent cell sorting at an unprecedented rate. It integrates high-throughput cell microscopy, focusing, sorting, and deep learning on a hybrid software-hardware data-management infrastructure, enabling real-time automated operation for data acquisition, data processing, intelligent decision-making, and actuation. I also show the broad utility of the technology to real-time image-activated sorting of microalgal and blood cells for studying photosynthesis and atherothrombosis, respectively. The technology is highly versatile and expected to enable machine-based scientific discovery in biological, pharmaceutical, and medical sciences.