Abstract

Microphysiological Systems Based on Microfluidic Device For Pharmacokinetic Studies

Hiroshi Kimura, Associate Professor, Tokai University

In this presentation, we will present integrated microfluidic platforms, which allow precise control of the cell culture environment on Microphysiological systems. Maintenance and replication of physiological functions of cells cultured in vitro are extremely difficult in conventional cell-based assay methods during life science and medical applications. Microfluidics is an emerging technology with the potential to provide integrated environments for maintenance, control, and monitoring the environment around cells. We work mainly in fundamental technologies of microfluidic devices and systems, and their applications to biological sciences including Microphysiological systems. A physiological environment in vitro can be replicated by fabrication of microstructures and control of microfluidics in these devices. Moreover, functional components, such as sensors, valves and pump, can be integrated into the devices by microfabrication methods. We performed cell-based assays to evaluate the function of these devices. Because cells cultured in vitro could be maintained and measured, these devices may be applied to medical, pharmaceutical and biological sciences.