Abstract

The Theranostic Potential of Membrane Hsp70 in Cancer: Development of a Liquid Biopsy and an Approach for Isolating Circulating Tumour Cells (CTCs)

Graham Pockley, • Director and Professor, John van Geest Cancer Research Centre, Nottingham Trent University

A cell surface bound form of the 70 kDa heat shock (stress) protein Hsp70 is selectively and widely expressed on the plasma membranes of many tumour entities. This presentation will describe the development of a liquid biopsy for identifying patients bearing membrane Hsp70-expressing tumours, the current status of an NK cell-based therapeutic for the treatment of such tumours, and, separately, the development of an approach for isolating circulating tumour cells (CTCs) based on their expression of membrane Hsp70.