Abstract

Probing the Extracellular RNA Landscape in Neurodegenerative Disease

Elizabeth Hutchins, Computational Scientist, The Translational Genomics Research Institute (TGen)

Molecular information from biofluids can be used to monitor and understand disease progression, identify biomarkers, develop assays, and for therapeutic discovery. The minimally invasive nature for collecting extracellular information from biofluids allows for frequent sampling, with the potential to closely monitor pathophysiological mechanisms of traumatic injury and disease. We have isolated and identified many types of extracellular RNA from biofluids using high-throughput RNA sequencing, including microRNA, protein coding RNA, lncRNA, and circRNA.