Abstract

Macrocyclization Processes in Flow

Shawn Collins, Professor, Université de Montréal

Traditional macrocyclization reactions often use batch reactors and/or apparatus for slow addition protocols. However, an emerging alternative exists in performing macrocyclizations in continuous flow. Continuous processing can offer several advantages, including higher yields and shorter reaction times due to improved mass and energy transfer. Continuous flow macrocyclizations involving the olefin metathesis reaction, the Glaser-Hay coupling, CuAAC as well as new photochemical macrocyclizations will be discussed.