Abstract

The Effects of ASC-Exosome on Dermatitis

Sun Jae Kwon, Director, ExoCoBio Exosome Institute, ExoCoBio Inc.

Exosome from human adipose tissue-derived mesenchymal stem cells (ASC-EXOSOME) was isolated from the serum-free conditioned media by sequential filtration and characterized as recommended by the International Society for Extracellular Vesicles (ISEV). Previously, we revealed that the ASC-EXOSOME alleviates the atopic dermatitis in an inflammatory murine model through down-regulation of multiple cytokine mRNA expression. As a subsequent study, we further analyzed the effects of ASC-EXOSOME on an alternative murine model of atopic dermatitis.  The effects of ASC-EXOSOME on the skin barrier function will be presented and discussed.