Abstract

Zero Hour Liquid Biopsies from Donor Kidneys

Bas van Balkom, Assistant Professor, University Medical Center Utrecht

Kidney transplantation is the preferred treatment for end-stage kidney disease, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive value for short- and long-term transplantation outcome, but are invasive and may not reflect the entire organ. Alternative, more representative methods to predict transplantation outcome are required. We hypothesized that preservation fluid contains proteins and exosomes could serve as biomarkers to predict post-transplantation graft function. We explored their presence and biomarkers potential and confirmed that secreted products in this fluid can be used to predict post-transplantation kidney function.