Abstract

Luncheon Technology Spotlight Presentation: BI/OND: Versatile Organ-on-Chip platform for 3D Tissues

Nikolas Gaio, CTO, BI/OND Solutions B.V.

Nowadays, biologists must choose between two options when running pre-clinical models in the early phase of drug testing: in vivo studies conducted on animals or in vitro screening. However, in vitro model and animals have shown to be inadequate for testing new pharmaceuticals to treat the many diseases that afflict humans. To achieve better medicine, there is a considerable need for more accurate human-representative systems. Therefore, biologists developed high-content 3D tissue models (organoids, microtissues, patient-derived tissues, etc..). However, they found that maintaining these 3D tissue models alive it is extremely complex. In particular, it is fundamental to control oxygen gradients and nutrients using a dynamic system. BIOND Solutions (BI/OND) supports biologists working in pharmaceutical companies, biotech and academia to explore fundamental questions about human health and diseases by providing versatile, dynamic chips for 3D tissue models. The approach consists in combining human cells, or patient-derived tissue with the use of a microfluidic chip.