Abstract

Single Step and Fast Membrane Pre-Concentration for Continuous Biosensing and Point-of-Care Diagnostic Devices

Jason Heikenfeld, Professor, University of Cincinnati

If there were a simple and passive technique, that would downshift the range of detection of all your sensors and analytes by 10-100X, what value would you place on such a breakthrough? Presented are single step and fast membrane pre-concentration devices for applications ranging from continuous wearable biosensing (sweat, interstitial fluid) to point of care diagnostics (blood, urine, saliva).  These devices now show >10X preconcentration in minutes for analytes ranging from small molecules (e.g. cortisol) to large proteins (influenza).  Further demonstrated are techniques that allow rapid adaptation of the devices for a wide variety of sensing modalities, including those sensitive to changes in pH or salinity.