Abstract

Extracellular RNA Signatures Associated with Parkinson’s Disease and Related Neurodegenerative Diseases

Amanda Lim, TGEN, Research Associate

A variety of RNAs are secreted into biofluids by every cell type, either packaged within extracellular vesicles (EVs) or bound to proteins. Extracellular RNAs present in biofluids can act as potential diagnostic or prognostic biomarkers for a wide range of diseases and injuries. This talk will focus on a biomarker study done to differentiate various forms of neurodegenerative disease, specifically Parkinson’s Disease. This preliminary study focuses on evaluating different sample prep and analysis methods to improve the accuracy of current biomarker models, resulting in improved diagnostic accuracy of similar neurological conditions. This talk will highlight the results of this analysis and where the research will go from here.