Abstract

Neural Exosomes - Therapeutic and Drug Delivery Potential in the Treatment of Neurodegenerative Diseases and Stroke

Steven Stice, Co-Founder and Chief Scientific Officer, Aruna Bio

Exosomes represent a promising approach to the future treatment of a number of disease states.  Aruna Bio is utilizing the power of exosomes, or nano-sized extracellular vesicles, to target diseased neural cells and facilitate their repair. The company’s lead exosome product, AB126, is derived from a proprietary neural stem cell line. AB126 crosses the blood-brain barrier and harbors unique neurogenic and angiogenic cargos (mRNA, miRNA, and protein), which have anti-inflammatory, neuroregenerative, and neuroprotective effects in multiple models of neurological disease.  Presentation will review data on neural stem cell derived exosomes and their potential both as a therapeutic and as a delivery vehicle.