Abstract

Modeling Cancer Prevention In Breast Organoids

Jennifer Rosenbluth, Instructor in Medicine, Dana-Farber Cancer Institute

Mammary organoids can be used to preserve complex lineages in long-term culture.  Using mass cytometry to profile cell states in patient-derived breast organoids, we identify a cell population that is expanded in the breast tissue of BRCA1/2 mutation carriers.  This approach is being extended to model early stages of cancer development as well as aggressive breast cancer subtypes.