Abstract

Microfluidic Cell Engineering for Precision Therapy

Abraham Lee, Professor, University of California Irvine

Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered.  That is, one must not only be able to identify molecular and cellular targets that are the source of disease but also understand how these targets behave in the body based on physiological principles.  Recent developments in microfluidics have contributed to burgeoning precision medicine fields such as liquid biopsy, immunotherapy, single cell analysis, genotyping and gene sequencing, and microphysiological systems.  A specific focus of my talk would be on microfluidic devices for engineering cells for developing targeted cell therapies and immunotherapies. These microfluidic technologies have the potential to close the loop from detection to diagnosis, to therapy.