Abstract

Applications of Organ-on-a-Chip Systems in Precision Medicine

Peter Ertl, Professor of Lab-on-a-Chip Systems, Vienna University of Technology

Organs-on-a-chip systems contain three-dimensional human living cell cultures that are grown in a dynamic microenvironment under controlled conditions. These microphysiological systems allow biological, chemical and physical manipulation and analysis of minimal functional units of human organs and tissues.  Consequently, organ-on-a-chip systems can be used to establish personalized disease models with the aim of providing clinical-relevant information from a patient’s own cells. In this presentation the current state and future of personalized medicine will discussed and two examples using primary cells and iPCS-derived organoids presented.