Abstract

Rapid Pre-Concentration for Salivary Measurement of Respiratory Viruses such as Influenza and COVID

Amy Drexelius, PhD Candidate, University of Cincinnati

If there were a simple and passive technique, that would downshift the range of detection of all your sensors and analytes by 10-100X, what value would you place on such a breakthrough? Presented are single step and fast membrane pre-concentration devices for applications ranging from continuous wearable biosensing (sweat, interstitial fluid) to point of care diagnostics (blood, urine, saliva), which can detect analytes present in respiratory viruses such as influenza and COVID-19.  These devices now show >10X preconcentration in minutes for analytes ranging from small molecules (e.g. cortisol) to large proteins (influenza).  Further demonstrated are techniques that allow rapid adaptation of the devices for a wide variety of sensing modalities, including those sensitive to changes in pH or salinity.