Abstract

3D Vascularized Lung Barrier Tissue Model in Organ-on-a-Chip Platform with an Open Access

Min Jae Song , Staff Scientist, National Center for Advancing Translational Sciences (NCATS)

NCATS tissue bioprinting lab developed a protocol for 3D vascularized lung barrier tissue models using a commercial organ on a chip platform with an open access (OrganoPlate® Graft). This open access enabled the formation of small airway or alveolar epithelium on the top of 3D vascularized construct, exhibiting comparable barrier functions. The presentation will describe this 3D lung barrier tissue on a chip including perfused vasculature with morphological and functional validations. I will further discuss the potential applications in modeling relevant diseases.