Abstract

Population Effect on Drug Metabolism and Absorption Using Ex Vivo Intestinal Tissue Explants in the Intestine Explant Barrier Chip

Joanne Donkers, Scientist, TNO

The Intestine Explant Barrier Chip integrates ex vivo intestinal tissue between two microchannels and enables drug permeability and metabolism studies under physiological conditions, including studying population effects in combination with microbiome supernatant.