Abstract

Defining the Role of Small Extracellular Vesicles in Lymph Node Pre-metastatic Niche Formation

Hector Peinado, Head, Spanish National Cancer Research Centre (CNIO)

We have analyzed the dynamics of tumor-derived small EVs (sEVs) in the lymphatic system and their role establishing the pre-metastatic niche formation in sentinel lymph nodes. Our data shows how both tumor intrinsic and extrinsic factors such as tumor-secreted sEVs are involved in lymphangiogenesis and pre-metastatic niche formation in sentinel lymph nodes through a neurotrophin receptor-dependent mechanism favoring metastatic spread in melanoma.