Abstract

Modeling Breast Cancer Development and Progression Using Patient-derived Organoids

Jennifer Rosenbluth, Assistant Professor, University of California-San Francisco

Breast organoids can preserve multiple complex cell states of both the normal mammary gland and breast tumors.  We describe our efforts to develop biobanks of normal and high risk breast organoids as well as breast tumor organoids.  These organoids can yield insights into rare, aggressive subtypes of breast cancer and can be used to screen anti-cancer compounds.