Abstract

All-in-One Optofluidic System for Molecular Biomarker Analysis

Holger Schmidt, Narinder Kapany Professor of Electrical Engineering, University of California-Santa Cruz

Optofluidics is the integration of integrated photonics with microfluidics in order to create more fully integrated labs--on-chip. I will discuss the development of a PDMS-based optofluidic platform that combines sample processing, an optical excitation source and optical analysis on a single chip. Planar liquid-core waveguide technology and the dynamic reconfigurability afforded by flexible chip materials are combined to create a new class of devices for ultrasensitive detection of molecular biomarkers with single molecule sensitivity. The incorporation of electronic integration and advanced signal processing methods for real-time analysis at the point of care will be discussed.