Abstract

Advancing Cancer Liquid Biopsy with Microfluidics and Nanoengineering

Yong Zeng, Associate Professor, University of Florida

A primary focus of my research is on the development of innovative microfluidics and nanobiosensing technologies and molecular biomarkers for cancer diagnosis and treatment. Herein, we will discuss some of the nanoengineered microfluidic systems for efficient immunoisolation of circulating extracellular vesicles (EVs) and ultrasensitive profiling of EV biomarkers, including proteins and miRNAs.  Adaptation of our new technologies to clinical studies of circulating EVs for non-invasive liquid biopsy of cancer will be discussed.