Abstract

Membrane Integration Strategies for Microfluidic Applications, Examples from Cell Culture and Organ on Chip

Stefano Begolo, Director of Engineering, ALine, Inc.

In this presentation we will review examples of commercially available porous membranes integrated into microfluidic devices. The properties of porous membranes have been leveraged to achieve cell co-culture, precision flow control, filtration and to control gas exchange between different solutions or compartments. These capabilities allow implementation of various applications into integrated microfluidic devices, including cell culture and Organ-on-Chip. We will also discuss integration strategies compatible with scale up manufacturing, to support commercialization of these devices.