Abstract

Mitochondria-Containing Extracellular Vesicles From Macrophages Support Active Resolution of Inflammatory Pain

Niels Eijkelkamp, Associate Professor, University Medical Center Utrecht

Pain normally serves as a warning sign of inflammation and damage, that disappears when inflammation and damage resolves. However, in a substantial number of patients with inflammatory diseases such as rheumatoid arthritis pain persists even after cessation of inflammation. In this presentation I will discuss some of our recent findings that the immune system is actively involved in the resolution of inflammatory pain and that the road towards new pain therapeutics may hold promise for extracellular vesicles as vehicles of mitochondrial transfer.